Transmission event of SARS-CoV-2 Delta variant reveals multiple vaccine breakthrough infections.

ABSTRACT:

Importance

Vaccine breakthrough by an emergent SARS-CoV-2 variant poses a great risk to global public health.

Objective

To determine the SARS-CoV-2 variant responsible for 6 cases of vaccine breakthrough.

Design

Nasopharyngeal swabs from suspected vaccine breakthrough cases were tested for SARS-CoV-2 by qPCR for Wuhan-Hu1 and Alpha variant. Positive samples were then sequenced by Swift Normalase Amplicon Panels to determine the causal variant.

Setting

Transmission event occurred at events surrounding a wedding outside of Houston, TX. Two patients from India, likely transmitted the Delta variant to other guests.

Participants

Following a positive SARS-CoV-2 qPCR test at a third-party site, six fully vaccinated patients were investigated. Three males and th

SUBMITTER: Farinholt T 

PROVIDER: S-EPMC8282118 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature