Exercise reduces circulating biomarkers of cellular senescence in humans.

ABSTRACT: Cellular senescence has emerged as a significant and potentially tractable mechanism of aging and multiple aging-related conditions. Biomarkers of senescent cell burden, including molecular signals in circulating immune cells and the abundance of circulating senescence-related proteins, have been associated with chronological age and clinical parameters of biological age in humans. The extent to which senescence biomarkers are affected by interventions that enhance health and function has not yet been examined. Here, we report that a 12-week structured exercise program drives significant improvements in several performance-based and self-reported measures of physical function in older adults. Impressively, the expression of key markers of the senescence program, including p16, p21, cGAS, a

SUBMITTER: Englund DA 

PROVIDER: S-EPMC8282238 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature