Age-related changes in metabolites in young donor livers and old recipient sera after liver transplantation from young to old rats.

ABSTRACT: Liver ageing not only damages liver function but also harms systemic metabolism. To better understand the mechanisms underlying liver ageing, we transplanted the livers of young rats to young and old rats and performed untargeted metabolomics to detect changes in the metabolites in the liver tissues and sera. A total of 153 metabolites in the livers and 83 metabolites in the sera were different between the old and young rats that did not undergo liver transplantation; among these metabolites, 7 different metabolites were observed in both the livers and sera. Five weeks after liver transplantation, the levels of 25 metabolites in the young donor livers were similar to those in the old rats, and this result probably occurred due to the effect of the whole-body environment of the older recipi

SUBMITTER: Han Q 

PROVIDER: S-EPMC8282239 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature