Chloride channel accessory 1 integrates chloride channel activity and mTORC1 in aging-related kidney injury.

ABSTRACT: The mechanism of kidney injury in aging are not well understood. In order to identify hitherto unknown pathways of aging-related kidney injury, we performed RNA-Seq on kidney extracts of young and aged mice. Expression of chloride (Cl) channel accessory 1 (CLCA1) mRNA and protein was increased in the kidneys of aged mice. Immunostaining showed a marked increase in CLCLA1 expression in the proximal tubules of the kidney from aged mice. Increased kidney CLCA1 gene expression also correlated with aging in marmosets and in a human cohort. In aging mice, increased renal cortical CLCA1 content was associated with hydrogen sulfide (H₂ S) deficiency, which was ameliorated by administering sodium hydrosulfide (NaHS), a source of H₂ S. In order to study whether increased CLCA1

SUBMITTER: Lee HJ 

PROVIDER: S-EPMC8282273 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature