Ontology highlight
ABSTRACT:
SUBMITTER: Lee HJ
PROVIDER: S-EPMC8282273 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Lee Hak Joo HJ Donati Andrew A Feliers Denis D Sun Yuyang Y Ding Yanli Y Madesh Muniswamy M Salmon Adam B AB Ikeno Yuji Y Ross Corinna C O'Connor Christopher L CL Ju Wenjun W Bitzer Markus M Chen Yidong Y Choudhury Goutam Ghosh GG Singh Brij B BB Sharma Kumar K Kasinath Balakuntalam S BS
Aging cell 20210612 7
The mechanism of kidney injury in aging are not well understood. In order to identify hitherto unknown pathways of aging-related kidney injury, we performed RNA-Seq on kidney extracts of young and aged mice. Expression of chloride (Cl) channel accessory 1 (CLCA1) mRNA and protein was increased in the kidneys of aged mice. Immunostaining showed a marked increase in CLCLA1 expression in the proximal tubules of the kidney from aged mice. Increased kidney CLCA1 gene expression also correlated with a ...[more]