Mitochondrial mistranslation modulated by metabolic stress causes cardiovascular disease and reduced lifespan.

ABSTRACT: Changes in the rate and fidelity of mitochondrial protein synthesis impact the metabolic and physiological roles of mitochondria. Here we explored how environmental stress in the form of a high-fat diet modulates mitochondrial translation and affects lifespan in mutant mice with error-prone (Mrps12^ep/ep ) or hyper-accurate (Mrps12^ha/ha ) mitochondrial ribosomes. Intriguingly, although both mutations are metabolically beneficial in reducing body weight, decreasing circulating insulin and increasing glucose tolerance during a high-fat diet, they manifest divergent (either deleterious or beneficial) outcomes in a tissue-specific manner. In two distinct organs that are commonly affected by the metabolic disease, the heart and th

SUBMITTER: Richman TR 

PROVIDER: S-EPMC8282274 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature