Chronological and biological aging of the human left ventricular myocardium: Analysis of microRNAs contribution.

ABSTRACT: Aging is the main risk factor for cardiovascular diseases. In humans, cardiac aging remains poorly characterized. Most studies are based on chronological age (CA) and disregard biological age (BA), the actual physiological age (result of the aging rate on the organ structure and function), thus yielding potentially imperfect outcomes. Deciphering the molecular basis of ventricular aging, especially by BA, could lead to major progresses in cardiac research. We aim to describe the transcriptome dynamics of the aging left ventricle (LV) in humans according to both CA and BA and characterize the contribution of microRNAs, key transcriptional regulators. BA is measured using two CA-associated transcriptional markers: CDKN2A expression, a cell senescence marker, and apparent age (AppAge), a high

SUBMITTER: Ramos-Marques E 

PROVIDER: S-EPMC8282276 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature