Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival.

ABSTRACT: Breast cancer heterogeneity in histology and molecular subtype influences metabolic and proliferative activity and hence the acid load on cancer cells. We hypothesized that acid-base transporters and intracellular pH (pH_i) dynamics contribute inter-individual variability in breast cancer aggressiveness and prognosis. We show that Na⁺,HCO₃^- cotransport and Na⁺/H⁺ exchange dominate cellular net acid extrusion in human breast carcinomas. Na⁺/H⁺ exchange elevates pH_i preferentially in estrogen receptor-negative breast carcinomas, whereas Na⁺,HCO₃^- cotransport raises pH_i more in invasive lobular than ductal breast carcinomas and in higher malignancy grad

SUBMITTER: Toft NJ 

PROVIDER: S-EPMC8282339 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature