Correlation between human health and reactive oxygen species produced in blood: a long-term chemiluminescence and fluorescence analysis.

ABSTRACT: The previous slide-glass type system could simultaneously detect reactive and highly reactive oxygen species, i.e., superoxide radicals (O₂^-·) and hypochlorite ions (OCl^-) elicited from leucocytes in sample blood, but had some drawbacks, i.e., signal noise from air-flow stirring, potential biohazard risks, etc. because of open samples placed on a slide glass. We overcame these drawbacks by adopting a fluidic-chip container in a new system, which resulted in higher sensitivity and more stable measurements. Using the new system, we conducted a pilot study on nominally healthy volunteers to find whether or not the monitored activities of leukocytes can distinguish more or less unhealthy conditions from healthy ones. At first, healthy volunteers of both genders

SUBMITTER: Kazumura K 

PROVIDER: S-EPMC8282623 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature