Identification of Three Loci Associated with Achilles Tendon Injury Risk from a Genome-wide Association Study.

ABSTRACT:

Purpose

This study aimed to screen the entire genome for genetic markers associated with risk for Achilles tendon injury.

Methods

A genome-wide association analysis was performed using data from the Kaiser Permanente Research Board and the UK Biobank. Achilles tendon injury cases were identified based on electronic health records from the Kaiser Permanente Research Board databank and the UK Biobank from individuals of European ancestry. Genome-wide association analyses from both cohorts were tested for Achilles tendon injury using a logistic regression model adjusting for sex, height, weight, and race/ethnicity using allele counts for single nucleotide polymorphisms (SNP). Previously identified genes within the literature were also tested for association with Achilles tendon

SUBMITTER: Kim SK 

PROVIDER: S-EPMC8282631 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature