Type 1 diabetes patients increase CXCR4⁺ and CXCR7⁺ haematopoietic and endothelial progenitor cells with exercise, but the response is attenuated.

ABSTRACT: Exercise mobilizes angiogenic cells, which stimulate vascular repair. However, limited research suggests exercise-induced increase of endothelial progenitor cell (EPCs) is completely lacking in type 1 diabetes (T1D). Clarification, along with investigating how T1D influences exercise-induced increases of other angiogenic cells (hematopoietic progenitor cells; HPCs) and cell surface expression of chemokine receptor 4 (CXCR4) and 7 (CXCR7), is needed. Thirty T1D patients and 30 matched non-diabetes controls completed 45 min of incline walking. Circulating HPCs (CD34⁺, CD34⁺CD45^dim) and EPCs (CD34⁺VEGFR2⁺, CD34⁺CD45^dimVEGFR2⁺), and subsequent expression of CXCR4 and CXCR7, were enumerated by flow cytometry

SUBMITTER: Taylor GS 

PROVIDER: S-EPMC8282661 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature