Essential roles of plexin-B3⁺ oligodendrocyte precursor cells in the pathogenesis of Alzheimer's disease.

ABSTRACT: The role of oligodendrocyte lineage cells, the largest glial population in the adult central nervous system (CNS), in the pathogenesis of Alzheimer's disease (AD) remains elusive. Here, we developed a culture method for adult oligodendrocyte progenitor cells (aOPCs). Fibroblast growth factor 2 (FGF2) promotes survival and proliferation of NG2⁺ aOPCs in a serum-free defined medium; a subpopulation (~5%) of plexin-B3⁺ aOPCs was also found. FGF2 withdrawal decreased NG2⁺, but increased plexin-B3⁺ aOPCs and Aβ1-42 secretion. Plexin-B3⁺ aOPCs were distributed throughout the adult rat brain, although less densely than NG2⁺ aOPCs. Spreading depolarization induced delayed cortical plexin-B3⁺ aOPC gliosis in the ipsilatera

SUBMITTER: Nihonmatsu-Kikuchi N 

PROVIDER: S-EPMC8282672 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature