Association Between Incident Delirium Treatment With Haloperidol and Mortality in Critically Ill Adults.

ABSTRACT:

Objectives

Haloperidol is commonly administered in the ICU to reduce the burden of delirium and its related symptoms despite no clear evidence showing haloperidol helps to resolve delirium or improve survival. We evaluated the association between haloperidol, when used to treat incident ICU delirium and its symptoms, and mortality.

Design

Post hoc cohort analysis of a randomized, double-blind, placebo-controlled, delirium prevention trial.

Setting

Fourteen Dutch ICUs between July 2013 and December 2016.

Patients

One-thousand four-hundred ninety-five critically ill adults free from delirium at ICU admission having an expected ICU stay greater than or equal to 2 days.

Interventions

Patients received preventive haloperidol or placebo for up to 28 days until

SUBMITTER: Duprey MS 

PROVIDER: S-EPMC8282692 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature