Rab34 GTPase mediates ciliary membrane formation in the intracellular ciliogenesis pathway.

ABSTRACT: The primary cilium is an essential organizing center for signal transduction, and ciliary defects cause congenital disorders known collectively as ciliopathies.^1-3 Primary cilia form by two pathways that are employed in a cell-type- and tissue-specific manner: an extracellular pathway in which the cilium grows out from the cell surface and an intracellular pathway in which the nascent cilium first forms inside the cell.^4-8 After exposure to the external environment, cilia formed via the intracellular pathway may have distinct functional properties, as they often remain recessed within a ciliary pocket.^9,10 However, the precise mechanism of intracellular ciliogenesis and its relatedness to extracellular ciliogenesis remain poorly unders

SUBMITTER: Ganga AK 

PROVIDER: S-EPMC8282722 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature