Transcriptome of rat subcortical white matter and spinal cord after spinal injury and cortical stimulation.

ABSTRACT: Spinal cord injury disrupts ascending and descending neural signals causing sensory and motor dysfunction. Neuromodulation with electrical stimulation is used in both clinical and research settings to induce neural plasticity and improve functional recovery following spinal trauma. However, the mechanisms by which electrical stimulation affects recovery remain unclear. In this study we examined the effects of cortical electrical stimulation following injury on transcription at several levels of the central nervous system. We performed a unilateral, incomplete cervical spinal contusion injury in rats and delivered stimulation for one week to the contralesional motor cortex to activate the corticospinal tract and other pathways. RNA was purified from bilateral subcortical white matter and 3

SUBMITTER: Kondiles BR 

PROVIDER: S-EPMC8282877 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature