Comprehensive Analysis of the Immune-Oncology Targets and Immune Infiltrates of N ⁶-Methyladenosine-Related Long Noncoding RNA Regulators in Breast Cancer.

ABSTRACT: Breast cancer (BRCA) has become the highest incidence of cancer due to its heterogeneity. To predict the prognosis of BRCA patients, sensitive biomarkers deserve intensive investigation. Herein, we explored the role of N ⁶-methyladenosine-related long non-coding RNAs (m⁶A-related lncRNAs) as prognostic biomarkers in BRCA patients acquired from The Cancer Genome Atlas (TCGA; n = 1,089) dataset and RNA sequencing (RNA-seq) data (n = 196). Pearson's correlation analysis, and univariate and multivariate Cox regression were performed to select m⁶A-related lncRNAs associated with prognosis. Twelve lncRNAs were identified to construct an m⁶A-related lncRNA prognostic signature (m⁶A-LPS) in TCGA training (n = 545) a

SUBMITTER: Zhang X 

PROVIDER: S-EPMC8283003 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature