Temporal Factors Modulate Haloperidol-Induced Conditioned Catalepsy.

ABSTRACT: Repeated pairings of a neutral context and the effects of haloperidol give rise to conditioned catalepsy when the context is subsequently presented in a drug-free test. In order to confirm whether this response is based on Pavlovian processes, we conducted two experiments involving two manipulations that affect conditioning intensity in classical conditioning procedures: time of joint exposure to the conditioned and the unconditioned stimulus, and the length of the inter-stimulus interval (ISI). The results revealed that both an increase in the length of context-drug pairings during conditioning and a reduced ISI between drug administration and context exposure increased conditioned catalepsy. These results are discussed in terms of the temporal peculiarities of those procedures that invol

SUBMITTER: Carcel L 

PROVIDER: S-EPMC8283013 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature