Factors influencing the acute pentylenetetrazole-induced seizure paradigm and a literature review.

ABSTRACT:

Objective

To confirm the critical factors affecting seizure susceptibility in acute pentylenetetrazole (PTZ) mouse epilepsy models and evaluate the prior literature for these factors.

Methods

Serial cohorts of wild-type mice administered intraperitoneal (IP)-PTZ were aggregated and analyzed by multivariate logistic regression for the effect of sex, age, background strain, dose, and physiologic stress (i.e., EEG implantation and/or single-housing) on seizure response. We assessed the reporting of these factors in a comprehensive literature review over the last 10 years (2010-2020).

Results

We conducted aggregated analysis of pooled data of 307 mice (220 C57BL/6J mice and 87 mixed background mice; 202 males, 105 females) with median age of 10 weeks (range: 6-49 weeks) w

SUBMITTER: Yuskaitis CJ 

PROVIDER: S-EPMC8283168 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature