Effect of Aerobic Exercise on White Matter Tract Microstructure in Young and Middle-Aged Healthy Adults.

ABSTRACT: Recent evidence suggests that being physically active can mitigate age-related white matter (WM) changes. In a randomized clinical trial, the effect of 6-month aerobic exercise (AE) or stretching/toning interventions on measures of WM microstructure (WMM) was assessed in a sample of 74 adults aged 20-67 years. Major WM pathways were reconstructed. No significant group-level change in WM tract microstructure following an AE training was observed. Without adjustment for multiple comparisons, an increase in fractional anisotropy (FA) and a decrease in mean diffusivity (MD) of the uncinate fasciculus were observed post-intervention in the AE group in comparison with the stretching group. In the AE group, a significant increase in cardiorespiratory fitness was measured but did not correlate wit

SUBMITTER: Predovan D 

PROVIDER: S-EPMC8283503 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature