Association of Monogenic and Polygenic Risk With the Prevalence of Open-Angle Glaucoma.

ABSTRACT:

Importance

Early diagnosis of open-angle glaucoma can lead to vision-saving treatment, and genetic variation is an increasingly powerful indicator in disease risk stratification.

Objective

To compare polygenic and monogenic variants in risk of glaucoma.

Design, setting, and participants

Clinical and genetic data were obtained for 2507 individuals from the Australian and New Zealand Registry of Advanced Glaucoma (ANZRAG) and 411 337 individuals in cross-sectional cohort studies including individuals of European ancestry in the UK Biobank. Recruitment to the UK Biobank occurred between 2006 and 2010, and data analysis occurred between September 2019 and August 2020.

Main outcomes and measures

Association of monogenic and polygenic variants with glaucoma risk.

SUBMITTER: Siggs OM 

PROVIDER: S-EPMC8283675 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature