Staphylococcal cassette chromosome mec containing a novel mec gene complex, B4.

ABSTRACT:

Objectives

To describe a new subclass of mec class B complex identified in Staphylococcus epidermidis.

Methods

Four S. epidermidis isolates obtained from bloodstream infections in patients at University Medical Center Groningen (UMCG) were analysed by phenotypic antibiotic susceptibility testing and WGS.

Results

Sequence analysis revealed a new staphylococcal cassette chromosome mec (SCCmec) structure in isolate UMCG335. In this structure, plasmid pUB110 was found to be integrated into SCCmec IVc, creating a new SCCmec subtype, IVUMCG335. SCCmec IVc and a copy of plasmid pUB110 were found in other isolates, UMCG364 and UMCG341, respectively, indicating a probability that SCCmec IVUMCG335 could have evolved at the UMCG. SCCmec of UMCG337 contained a new genetic organiz

SUBMITTER: Sabat AJ 

PROVIDER: S-EPMC8283725 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature