Short leukocyte telomeres predict 25-year Alzheimer's disease incidence in non-APOE ε4-carriers.

ABSTRACT:

Background

Leukocyte telomere length (LTL) has been shown to predict Alzheimer's disease (AD), albeit inconsistently. Failing to account for the competing risks between AD, other dementia types, and mortality, can be an explanation for the inconsistent findings in previous time-to-event analyses. Furthermore, previous studies indicate that the association between LTL and AD is non-linear and may differ depending on apolipoprotein E (APOE) ε4 allele carriage, the strongest genetic AD predictor.

Methods

We analyzed whether baseline LTL in interaction with APOE ε4 predicts AD, by following 1306 initially non-demented subjects for 25 years. Gender- and age-residualized LTL (rLTL) was categorized into tertiles of short, medium, and long rLTLs. Two complementary time-to-event mode

SUBMITTER: Hackenhaar FS 

PROVIDER: S-EPMC8283833 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature