Global analysis of protein lysine 2-hydroxyisobutyrylation (K_hib) profiles in Chinese herb rhubarb (Dahuang).

ABSTRACT:

Background

Lysine 2-hydroxyisobutyrylation (K_hib) is a newly discovered protein posttranslational modification (PTM) and is involved in the broad-spectrum regulation of cellular processes that are found in both prokaryotic and eukaryotic cells, including in plants. The Chinese herb rhubarb (Dahuang) is one of the most widely used traditional Chinese medicines in clinical applications. To better understand the physiological activities and mechanism of treating diseases with the herb, it is necessary to conduct intensive research on rhubarb. However, K_hib modification has not been reported thus far in rhubarb.

Results

In this study, we performed the first global analysis of K_hib-modified proteins in rhubarb by using sensitive affinity enrichmen

SUBMITTER: Qi T 

PROVIDER: S-EPMC8283887 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature