Meta-analysis of sleep deprivation in the acute treatment of bipolar depression.

ABSTRACT:

Background

Sleep deprivation (SD) is an antidepressant intervention with multiple administration formats that has been investigated primarily with uncontrolled clinical trials and qualitative reviews of the literature. The validity and applicability of these findings to the treatment of bipolar depression (BPD) is uncertain.

Methods

A PRISMA-based systematic review of the literature and meta-analysis were conducted to determine the efficacy of SD in the treatment of BPD and to identify moderator variables that influence response rate.

Results

From a sample of 15 studies covering 384 patients, the overall, mean response rate to SD was 47.6% (CI 36.0%, 59.5%). This response rate compared post-SD to pre-SD depression scores, and not to a placebo control condition. Of sev

SUBMITTER: Gottlieb JF 

PROVIDER: S-EPMC8283955 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature