Radiopharmaceutical and Eu³⁺ doped gadolinium oxide nanoparticles mediated triple-excited fluorescence imaging and image-guided surgery.

ABSTRACT: Cerenkov luminescence imaging (CLI) is a novel optical imaging technique that has been applied in clinic using various radionuclides and radiopharmaceuticals. However, clinical application of CLI has been limited by weak optical signal and restricted tissue penetration depth. Various fluorescent probes have been combined with radiopharmaceuticals for improved imaging performances. However, as most of these probes only interact with Cerenkov luminescence (CL), the low photon fluence of CL greatly restricted it's interaction with fluorescent probes for in vivo imaging. Therefore, it is important to develop probes that can effectively convert energy beyond CL such as β and γ to the low energy optical signals. In this study, a Eu³⁺ doped gadolinium oxide (Gd₂O₃

SUBMITTER: Shi X 

PROVIDER: S-EPMC8283963 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature