The effects of genetic polymorphisms on benzene-exposed workers: A systematic review.

ABSTRACT:

Background and aims

Benzene is a group I carcinogen, which has been associated with leukemia and myelodysplastic syndrome. Moreover, it has been proposed that polymorphisms in benzene metabolizing genes influence the outcomes of benzene exposure in the human body. This systematic review aims to elucidate the existent relationship between genetic polymorphisms and the risk of developing adverse health effects in benzene-exposed workers.

Methods

Three databases were systematically searched until April 2020. The preferred reporting items for systematic reviews and meta-analyses method was used to select articles published between 2005 and 2020. Quality assessment and risk of bias were evaluated by the Newcastle-Ottawa scale.

Results

After full-text evaluation, 36 article

SUBMITTER: Ramirez-Lopera V 

PROVIDER: S-EPMC8284097 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature