A comprehensive investigation on liver regeneration: a meta-analysis and systems biology approach.

ABSTRACT:

Aim of the study

Liver regeneration is one of the essential fields of regenerative medicine as a branch of tissue engineering and molecular biology that draws global researchers' attention. This study aims to conduct a systematic review and meta-analysis on the high-throughput gene expression microarray dataset of liver regeneration on the NCBI-GEO database to identify the significant genes and signaling pathways and confirm the genes from literature studies on associated diseases.

Material and methods

We thoroughly searched the NCBI-GEO database to retrieve and screen the GEO microarray datasets' contents. Due to the inclusion of different species in eligible GEO datasets in the meta-analysis, the list of significant genes for the random-effects model were identified. Moreo

SUBMITTER: Asnaashari S 

PROVIDER: S-EPMC8284170 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature