Dynamic glial response and crosstalk in demyelination-remyelination and neurodegeneration processes.

ABSTRACT: Multiple sclerosis is an autoimmune disease in which the immune system attacks the myelin sheath in the central nervous system. It is characterized by blood-brain barrier dysfunction throughout the course of multiple sclerosis, followed by the entry of immune cells and activation of local microglia and astrocytes. Glial cells (microglia, astrocytes, and oligodendrocyte lineage cells) are known as the important mediators of neuroinflammation, all of which play major roles in the pathogenesis of multiple sclerosis. Network communications between glial cells affect the activities of oligodendrocyte lineage cells and influence the demyelination-remyelination process. A finely balanced glial response may create a favorable lesion environment for efficient remyelination and neuroregeneration. Th

SUBMITTER: Chu T 

PROVIDER: S-EPMC8284258 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature