Progress in clinical trials of stem cell therapy for cerebral palsy.

ABSTRACT: Cerebral palsy is the most common disease in children associated with lifelong disability in many countries. Clinical research has demonstrated that traditional physiotherapy and rehabilitation therapies cannot alone cure cerebral palsy. Stem cell transplantation is an emerging therapy that has been applied in clinical trials for a variety of neurological diseases because of the regenerative and unlimited proliferative capacity of stem cells. In this review, we summarize the design schemes and results of these clinical trials. Our findings reveal great differences in population characteristics, stem cell types and doses, administration methods, and evaluation methods among the included clinical trials. Furthermore, we also assess the safety and efficacy of these clinical trials. We anticip

SUBMITTER: Lv ZY 

PROVIDER: S-EPMC8284300 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature