A prospective study of the relationships between change in body composition and cardiovascular risk factors across the menopause.

ABSTRACT:

Objective

Menopause increases the risk of cardiovascular disease (CVD) which in part has been attributed to the rise in cholesterol and blood pressure (BP). This study examined the hypothesis that menopausal changes in body composition and regional fat depots relate to the change in CVD risk factors.

Methods

A prospective recall study was designed to capture premenopausal women to be re-examined soon after menopause. A total of 97 women from the Oxford Biobank underwent dual x-ray absorptiometry, blood biochemistry, and BP readings pre- and postmenopause.

Results

Despite minimal changes in body weight over the 5.1 ± 0.9 year follow-up period, there was an increase in total fat mass and a decline in lean mass, where the proportional change of regional fat mass was the

SUBMITTER: Dehghan A 

PROVIDER: S-EPMC8284369 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature