System Genetics Including Causal Inference Identify Immune Targets for Coronary Artery Disease and the Lifespan.

ABSTRACT:

Background

Randomized clinical trials indicate that the immune response plays a significant role in coronary artery disease (CAD), a disorder impacting the lifespan potential. However, the identification of targets critical to the immune response in atheroma is still hampered by a lack of solid inference.

Methods

Herein, we implemented a system genetics approach to identify causally associated immune targets implicated in atheroma. We leveraged genome-wide association studies to perform mapping and Mendelian randomization to assess causal associations between gene expression in blood cells with CAD and the lifespan. Expressed genes (eGenes) were prioritized in network and in single-cell expression derived from plaque immune cells.

Results

Among 840 CAD-associated bloo

SUBMITTER: Bon-Baret V 

PROVIDER: S-EPMC8284374 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature