Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC8284395 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Li Yuchen Y Zeng Weihong W Li Tong T Guo Yanyan Y Zheng Guangyong G He Xiaoying X Bai Lilian L Ding Guolian G Jin Li L Liu Xinmei X
Frontiers in genetics 20210702
Intrathymic differentiation of T lymphocytes begins as early as intrauterine stage, yet the T cell lineage decisions of human fetal thymocytes at different gestational ages are not currently understood. Here, we performed integrative single-cell analyses of thymocytes across gestational ages. We identified conserved candidates underlying the selection of T cell receptor (TCR) lineages in different human fetal stages. The trajectory of early thymocyte commitment during fetal growth was also chara ...[more]