Effects of bradykinin on voltage-gated K_V 4 channels in muscle dorsal root ganglion neurons of rats with experimental peripheral artery disease.

ABSTRACT:

Key points

During exercise, bradykinin (BK), a muscle metabolite in ischaemic muscles, exaggerates autonomic responses to activation of muscle afferent nerves in peripheral artery disease (PAD). We examined whether BK inhibits activity of K_V 4 channels in muscle afferent neurons of PAD rats induced by femoral artery occlusion. We demonstrated that: 1) femoral occlusion attenuates K_V 4 currents in dorsal root ganglion (DRG) neurons innervating the hindlimb muscles and decreases the threshold of action potential firing; 2) BK has a greater inhibitory effect on K_V 4 currents in muscle DRG neurons of PAD rats; and 3) expression of K_V 4.3 is downregulated in DRGs of PAD rats and inhibition of K_V 4.3 significantly decreases activity

SUBMITTER: Li Q 

PROVIDER: S-EPMC8284427 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature