Radiological assessment schedule for 1p/19q-codeleted gliomas during the surveillance period using parametric modeling.

ABSTRACT:

Background

There have been no evidence-based guidelines on the optimal schedule for the radiological assessment of 1p/19q-codeleted glioma. This study aimed to recommend an appropriate radiological evaluation schedule for 1p/19q-codeleted glioma during the surveillance period through parametric modeling of the progression-free survival (PFS) curve.

Methods

A total of 234 patients with 1p/19q-codeleted glioma (137 grade II and 97 grade III) who completed regular treatment were retrospectively reviewed. The patients were stratified into each layered progression risk group by recursive partitioning analysis. A piecewise exponential model was used to standardize the PFS curves. The cutoff value of the progression rate among the remaining progression-free patients was set to 10%

SUBMITTER: Kang H 

PROVIDER: S-EPMC8284622 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature