Plasma IL-8 and ICOSLG as prognostic biomarkers in glioblastoma.

ABSTRACT:

Background

CNS immune privilege has been challenged in recent years. Glioblastoma (GBM) immune dysfunction includes complex interactions with the immune system outside the CNS. The aim of this study was to determine diagnostic and prognostic potential of immune-related proteins in plasma in GBM and interrogate biomarker presence in the brain tumor microenvironment (TME).

Methods

One hundred and fifty-eight patients with glioma WHO grade II-IV were included. Plasma collected at surgery was screened for 92 proteins using proximity extension assay technology and related to clinical outcome. Secretion and expression of candidate prognostic biomarkers were subsequently analyzed in 8 GBM cell lines and public RNAseq data.

Results

Plasma levels of 20 out of 92 screened prote

SUBMITTER: Holst CB 

PROVIDER: S-EPMC8284624 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature