Metabolic Brain Network Analysis With ¹⁸F-FDG PET in a Rat Model of Neuropathic Pain.

ABSTRACT: Neuropathic pain has been found to be related to profound reorganization in the function and structure of the brain. We previously demonstrated changes in local brain activity and functional/metabolic connectivity among selected brain regions by using neuroimaging methods. The present study further investigated large-scale metabolic brain network changes in 32 Sprague-Dawley rats with right brachial plexus avulsion injury (BPAI). Graph theory was applied in the analysis of 2-deoxy-2-[18F] fluoro-D-glucose (¹⁸F-FDG) PET images. Inter-subject metabolic networks were constructed by calculating correlation coefficients. Global and nodal network properties were calculated and comparisons between pre- and post-BPAI (7 days) status were conducted. The global network properties (includi

SUBMITTER: Huo BB 

PROVIDER: S-EPMC8284720 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature