Mechanical feedback and robustness of apical constrictions in Drosophila embryo ventral furrow formation.

ABSTRACT: Formation of the ventral furrow in the Drosophila embryo relies on the apical constriction of cells in the ventral region to produce bending forces that drive tissue invagination. In our recent paper we observed that apical constrictions during the initial phase of ventral furrow formation produce elongated patterns of cellular constriction chains prior to invagination and argued that these are indicative of tensile stress feedback. Here, we quantitatively analyze the constriction patterns preceding ventral furrow formation and find that they are consistent with the predictions of our active-granular-fluid model of a monolayer of mechanically coupled stress-sensitive constricting particles. Our model shows that tensile feedback causes constriction chains to develop along underlying precurs

SUBMITTER: Holcomb MC 

PROVIDER: S-EPMC8284804 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature