Osteonecrosis of the jaw risk factors in bisphosphonate-treated patients with metastatic cancer.

ABSTRACT:

Background

A case-control study was performed to define clinical and genetic risk factors associated with osteonecrosis of the jaw in patients with metastatic cancer treated with bisphosphonates.

Methods

Clinical data and tissues were collected from patients treated with bisphosphonates for metastatic bone disease who were diagnosed with osteonecrosis of the jaw (cases) and matched controls. Clinical data included patient, behavioral, disease, and treatment information. Genetic polymorphisms in CYP2C8 (rs1934951) and other candidate genes were genotyped. Odds ratios from conditional logistic regression models were examined to identify clinical and genetic characteristics associated with case or control status.

Results

The study population consisted of 76 cases and 126

SUBMITTER: Van Poznak C 

PROVIDER: S-EPMC8284838 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature