Familial Risk of Inflammatory Bowel Disease: A Population-Based Cohort Study in South Korea.

ABSTRACT:

Background & aims

Despite the rapid increase in inflammatory bowel disease (IBD), population-level familial risk estimates of IBDs still are lacking in Asian-Pacific countries. We aimed to quantify the familial risk of incident IBD among first-degree relatives (FDRs) of individuals with IBD according to age, sex, and familial relationship.

Methods

Using the South Korea National Health Insurance database (2002-2017), which has complete population coverage and confirmed accuracy of both FDR information and IBD diagnoses, we constructed a cohort of 21,940,795 study subjects comprising 12 million distinct families. We calculated incidence risk ratios of ulcerative colitis (UC) or Crohn's disease (CD) in individuals of affected FDRs compared with individuals without affected FDRs

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC8284845 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature