Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) modulates T1DM susceptibility by gut microbiota.

ABSTRACT: Nucleotide-binding oligomerization domain-containing protein 2 (Nod2) is an innate immune receptor. To investigate the role of Nod2 in susceptibility to the autoimmune disease, type 1 diabetes mellitus (T1DM), we generated Nod2^-/- non-obese diabetic (NOD) mice. The Nod2^-/-NOD mice had different composition of the gut microbiota compared to Nod2^+/+NOD mice and were significantly protected from diabetes, but only when housed separately from Nod2^+/+NOD mice. This suggested that T1DM susceptibility in Nod2^-/-NOD mice is dependent on the alteration of gut microbiota, which modulated the frequency and function of IgA-secreting B-cells and IL-10 promoting T-regulatory cells. Finally, colonizing germ-free NOD mice with Nod2^-/-NOD gu

SUBMITTER: Li YY 

PROVIDER: S-EPMC8284907 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature