Do acute hepatopancreatic necrosis disease-causing PirAB^VP toxins aggravate vibriosis?

ABSTRACT: Gram-negative marine bacterium Vibrio parahaemolyticus is an important aquatic pathogen and has been demonstrated to be the causative agent of acute hepatopancreatic necrotic disease (AHPND) in shrimp aquaculture. The AHPND-causing V. parahaemolyticus strains contain a pVA1 plasmid encoding the binary PirA^VP and PirB^VP toxins, are the primary virulence factor that mediates AHPND and mortality in shrimp. Since PirAB^VP toxins are secreted extracellularly, one can hypothesize that PirAB^VP toxins would aggravate vibriosis in the aquatic environment. To address this, in vivo and in vitro experiments were conducted. Germ-free Artemia franciscana were co-challenged with PirAB^VP toxins and 10 Vibrio sp

SUBMITTER: Tran PTN 

PROVIDER: S-EPMC8284973 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature