Low-Density Neutrophils in Healthy Individuals Display a Mature Primed Phenotype.

ABSTRACT: Neutrophils are the most abundant leukocytes in human peripheral blood, comprising about 70% of all leukocytes. They are regarded as the first line of defense of the innate immune system, but neutrophils have also the ability of regulating the adaptive immune response. Recently, However, multiple phenotypes and functional states of neutrophils have been reported, particularly in inflammation, autoimmunity, and cancer. One possible subtype of neutrophils, the so-called low-density neutrophils (LDN) is found among mononuclear cells (MNC), monocytes and lymphocytes, after separating the leukocytes from blood by density gradient centrifugation. LDN increase in numbers during several pathological conditions. However, LDN present in healthy conditions have not been investigated further. Therefor

SUBMITTER: Blanco-Camarillo C 

PROVIDER: S-EPMC8285102 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature