Novel genetic variants associated with brain functional networks in 18,445 adults from the UK Biobank.

ABSTRACT: Here, we investigated the genetics of weighted functional brain network graph theory measures from 18,445 participants of the UK Biobank (44-80 years). The eighteen measures studied showed low heritability (mean h²_SNP = 0.12) and were highly genetically correlated. One genome-wide significant locus was associated with strength of somatomotor and limbic networks. These intergenic variants were located near the PAX8 gene on chromosome 2. Gene-based analyses identified five significantly associated genes for five of the network measures, which have been implicated in sleep duration, neuronal differentiation/development, cancer, and susceptibility to neurodegenerative diseases. Further analysis found that somatomotor network strength was phenotypically associated with sle

SUBMITTER: Foo H 

PROVIDER: S-EPMC8285376 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature