Ontology highlight
ABSTRACT:
SUBMITTER: Zhao Z
PROVIDER: S-EPMC8285429 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Zhao Zhe Z Wang Huimeng H Shi Mai M Zhu Tianyuan T Pediongco Troi T Lim Xin Yi XY Meehan Bronwyn S BS Nelson Adam G AG Fairlie David P DP Mak Jeffrey Y W JYW Eckle Sidonia B G SBG de Lima Moreira Marcela M Tumpach Carolin C Bramhall Michael M Williams Cameron G CG Lee Hyun Jae HJ Haque Ashraful A Evrard Maximilien M Rossjohn Jamie J McCluskey James J Corbett Alexandra J AJ Chen Zhenjun Z
Nature communications 20210716 1
Mucosal-associated Invariant T (MAIT) cells are recognized for their antibacterial functions. The protective capacity of MAIT cells has been demonstrated in murine models of local infection, including in the lungs. Here we show that during systemic infection of mice with Francisella tularensis live vaccine strain results in evident MAIT cell expansion in the liver, lungs, kidney and spleen and peripheral blood. The responding MAIT cells manifest a polarised Th1-like MAIT-1 phenotype, including t ...[more]