Comprehensive characterization of distinct genetic alterations in metastatic breast cancer across various metastatic sites.

ABSTRACT: Metastasis is the major cause of death in breast cancer patients. Although previous large-scale analyses have identified frequently altered genes specific to metastatic breast cancer (MBC) compared with those in primary breast cancer (PBC), metastatic site-specific altered genes in MBC remain largely uncharacterized. Moreover, large-scale analyses are required owing to the low expected frequency of such alterations, likely caused by tumor heterogeneity and late dissemination of breast cancer. To clarify MBC-specific genetic alterations, we integrated publicly available clinical and mutation data of 261 genes, including MBC drivers, from 4268 MBC and 5217 PBC patients from eight different cohorts. We performed meta-analyses and logistic regression analyses to identify MBC-enriched genetic a

SUBMITTER: Cha S 

PROVIDER: S-EPMC8285498 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature