Balancing precision versus cohort transcriptomic analysis of acute and recovery phase of viral bronchiolitis.

ABSTRACT: Viral infections affecting the lower respiratory tract place enormous burdens on hospitals. As neither vaccines nor antiviral agents exist for many viruses, understanding risk factors and outcomes in each patient using minimally invasive analysis, such as blood, can lead to improved health care delivery. A cohort of PAXgene RNA sequencing of infants admitted with moderate or severe acute bronchiolitis and respiratory syncytial virus were compared with case-control statistical analysis and cohort-based outlier mapping for precision transcriptomics. Patients with severe bronchiolitis had signatures connected to the immune system, interferon signaling, and cytokine signaling, with marked sex differences in XIST, RPS4Y1, KDM5D, and LINC00278 for severity. Several pa

SUBMITTER: Gupta R 

PROVIDER: S-EPMC8285625 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature