EQTpLot: a user-friendly R package for the visualization of colocalization between eQTL and GWAS signals.

ABSTRACT:

Background

Genomic studies increasingly integrate expression quantitative trait loci (eQTL) information into their analysis pipelines, but few tools exist for the visualization of colocalization between eQTL and GWAS results. Those tools that do exist are limited in their analysis options, and do not integrate eQTL and GWAS information into a single figure panel, making the visualization of colocalization difficult.

Results

To address this issue, we developed the intuitive and user-friendly R package eQTpLot. eQTpLot takes as input standard GWAS and cis-eQTL summary statistics, and optional pairwise LD information, to generate a series of plots visualizing colocalization, correlation, and enrichment between eQTL and GWAS signals for a given gene-trait pair. With eQTpLot, inv

SUBMITTER: Drivas TG 

PROVIDER: S-EPMC8285863 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature