Separation of presynaptic Ca_v2 and Ca_v1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca²⁺ pump PMCA.

ABSTRACT: Synaptic vesicle (SV) release, recycling, and plastic changes of release probability co-occur side by side within nerve terminals and rely on local Ca²⁺ signals with different temporal and spatial profiles. The mechanisms that guarantee separate regulation of these vital presynaptic functions during action potential (AP)-triggered presynaptic Ca²⁺ entry remain unclear. Combining Drosophila genetics with electrophysiology and imaging reveals the localization of two different voltage-gated calcium channels at the presynaptic terminals of glutamatergic neuromuscular synapses (the Drosophila Ca_v2 homolog, Dmca1A or cacophony, and the Ca_v1 homolog, Dmca1D) but with spatial and functional separation. Ca_v2 within active zones is

SUBMITTER: Krick N 

PROVIDER: S-EPMC8285953 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature