A self-powered implantable and bioresorbable electrostimulation device for biofeedback bone fracture healing.

ABSTRACT: Electrostimulation has been recognized as a promising nonpharmacological treatment in orthopedics to promote bone fracture healing. However, clinical applications have been largely limited by the complexity of equipment operation and stimulation implementation. Here, we present a self-powered implantable and bioresorbable bone fracture electrostimulation device, which consists of a triboelectric nanogenerator for electricity generation and a pair of dressing electrodes for applying electrostimulations directly toward the fracture. The device can be attached to irregular tissue surfaces and provide biphasic electric pulses in response to nearby body movements. We demonstrated the operation of this device on rats and achieved effective bone fracture healing in as short as 6 wk versus the con

SUBMITTER: Yao G 

PROVIDER: S-EPMC8285966 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature