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PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice.

ABSTRACT: Ultrasonic hearing and vocalization are the physiological mechanisms controlling echolocation used in hunting and navigation by microbats and bottleneck dolphins and for social communication by mice and rats. The molecular and cellular basis for ultrasonic hearing is as yet unknown. Here, we show that knockout of the mechanosensitive ion channel PIEZO2 in cochlea disrupts ultrasonic- but not low-frequency hearing in mice, as shown by audiometry and acoustically associative freezing behavior. Deletion of Piezo2 in outer hair cells (OHCs) specifically abolishes associative learning in mice during hearing exposure at ultrasonic frequencies. Ex vivo cochlear Ca2+ imaging has revealed that ultrasonic transduction requires both PIEZO2 and the hair-cell mechanotransduction channel. The present study demonstrates that OHCs serve as effector cells, combining with PIEZO2 as an essential molecule for ultrasonic hearing in mice.

SUBMITTER: Li J 

PROVIDER: S-EPMC8285978 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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PIEZO2 mediates ultrasonic hearing via cochlear outer hair cells in mice.

Li Jie J   Liu Shuang S   Song Chenmeng C   Hu Qun Q   Zhao Zhikai Z   Deng Tuantuan T   Wang Yi Y   Zhu Tong T   Zou Linzhi L   Wang Shufeng S   Chen Jiaofeng J   Liu Lian L   Hou Hanqing H   Yuan Kexin K   Zheng Hairong H   Liu Zhiyong Z   Chen Xiaowei X   Sun Wenzhi W   Xiao Bailong B   Xiong Wei W  

Proceedings of the National Academy of Sciences of the United States of America 20210701 28

Ultrasonic hearing and vocalization are the physiological mechanisms controlling echolocation used in hunting and navigation by microbats and bottleneck dolphins and for social communication by mice and rats. The molecular and cellular basis for ultrasonic hearing is as yet unknown. Here, we show that knockout of the mechanosensitive ion channel PIEZO2 in cochlea disrupts ultrasonic- but not low-frequency hearing in mice, as shown by audiometry and acoustically associative freezing behavior. Del  ...[more]

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