LncRNA AC007255.1, an immune-related prognostic enhancer RNA in esophageal cancer.

ABSTRACT:

Background

Growing evidence has suggested that enhancer RNAs (eRNAs), a set of long non-coding RNAs (lncRNAs) that were derived from active enhancer regions, play critical roles in regulating gene expression in human cancers. Nevertheless potential functions of eRNAs in esophageal cancer ESCA have not yet been expounded. Here, this study aimed to explore key prognostic eRNAs in ESCA.

Methods

LncRNAs that were transcribed from active enhancer regions were analyzed utilizing the PreSTIGE algorithm, followed by prediction of their target genes. Based on the ESCA RNA-seq data from the TANRIC database, overall survival (OS)-related eRNAs were determined. The correlation between AC007255.1 expression and various clinical traits of ESCA was calculated. Functional enrichment analysi

SUBMITTER: Wang Q 

PROVIDER: S-EPMC8286057 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature